LSD

Chemical Name:

d-Lysergic acid diethylamide

Street Names:

LSD, LSD-25, Lucy, L, Acid, Cid, Tabs, Blotter

Category:

Psychedelic

Subcategory:

Lysergamide

Bioavailability:

71%

LSD Dosage

Threshold

Light

Common

5-10 µg

25 - 75 µg

75 - 200 µg

Strong

Heavy

Fatal

200 - 400 µg

400 µg +

Unknown

Warning

Remember: Always start on lower dosages! Differences in metabolism, tolerance, sensitivity, and neurochemistry can lead to higher than expected effects, and even death.

LSD Duration

Onset

Come up

Peak

15 - 30 minutes

45 - 120 minutes

3 - 5 hours

Comedown

After effects

Total

3 - 5 hours

12 - 48 hours

8 - 12 hours

Interactions

This substance interacts with:

Lithium

Tramadol

Stimulants

Marijuana

Anticholinergics

These interactions may lead to an unpleasant experiences due to substances potentiating each other unpredictably, and/or may be potentially fatal.

LSD


Lysergic acid diethylamide (Abbreviated as LSD and also known as LSD-25, Lucy, L, and Acid) is a psychedelic of the lysergamide family of chemicals. While it was discovered in 1938 by Albert Hofmann, LSD's hallucinogenic properties were not discovered until five years later when Albert Hofmann accidentally ingested the compound [1]. LSD became an integral symbol of hippie counter-culture later on in the 1960s, as well as becoming a staple of general drug culture. LSD is among the most culturally influential psychedelic drugs in the world. It is believed to change a person's perspective of reality by temporarily inducing a state of interconnection in parts of the brain that don't typically communicate with each other and by impacting the effects of multiple neurotransmitters.[2]

Harm Reduction

As with any mind-altering substance, there's no truly "safe" way to consume them. While LSD is not toxic under normal dosages [3], nor does it cause any long term physical damage to the brain. LSD can, however, be mentally traumatizing in the case of a bad experience and cause the user to put themselves in harm's way. The use of psychedelics can also have negative effects on mental health for some.

LSD Blotter

LSD is more recreational than other traditional psychedelics, but it still has the potential for nightmarish experiences and enlightening/life-changing ones. LSD can allow users to open up emotionally, and use this change of perspective to view their problems in a new, and often positive light. Studies show that LSD showed promising results in preliminary trials for the treatment of depression in psychedelic-assisted psychotherapy. [4] [5] [6]

man with psychedelic patterns

One of the biggest dangers of consuming LSD is getting a drug that isn't LSD. To increase profit margins, some dealers sell people blotterss that contain different substances, often 25i-NBOMe. Due to these being cheaper to mass produce and buy than LSD, some dealers prefer to sell these alternative chemicals to people and claim they are LSD to save themselves money. However, these chemicals (particularly NBOx compounds) don't have the same safety profile as LSD due to physical toxicity or lack of research. Due to dealer irresponsibility, some 25i-NBOMe tabs may contain MUCH more than the common "safe" dose, which can lead to seizures, psychosis, and death. [7]

25i-NBOMe

Set and setting is vital before taking LSD. If anyone is planning to trip on LSD, they should be in a positive mood before going into the experience (set). One's surroundings also have a massive effect on the trip, and anyone who is taking this substance should be comfortable with their environment and any people around them.

Set and Setting

Any slight fear can be amplified during a trip. If the person tripping is somewhere where they don't feel safe or are with people they don't know or trust, then paranoia can quickly build-up. [8]

Due to the nature of LSD, it's important to have someone else with you while tripping. During the state of mind, LSD puts you in, it's easy to become trapped in a phenomenon known as a "thought loop". In a thought loop, the person tripping might have thoughts repeat over and over in a cycle. These looping thoughts can result in a sense of déjà vu, which can be confusing to the user.

Trippy Alien

A trip sitter is recommended for most people who are going to ingest any hallucinogenic substance. A trip sitter can calm down the person having any type of delusion, or provide the person tripping with a "trip killer".

Xanax

A trip killer is a drug (typically a sedative) that's used to calm down a person tripping if they're having a distressing experience. Often, trip killers are sedatives. They could be benzos[9], or antipsychotics. [10] Popular options for trip killers are:

  1. Xanax (Alprazolam)
  2. Diazepam (Valium)
  3. Etizolam (A research benzo)
  4. Risperidone (Risperdal)
  5. Ketanserin
  6. Clozapine (Versacloz)
  7. Nefazodone
  8. Seroquel (Quetiapine)
  9. Thorazine (Chlorpromazine)

It's advisable to start slow and slowly go up in dosage. Don't jump straight into a 500ug LSD trip if it's your first time trying the substance unless you have extensive experience with other psychedelics. Avoid mixing LSD with cannabis (weed, marijuana) since weed can unpredictably potentiate the effects of LSD to an uncomfortable degree. [11]

Trippy Art

Furthermore, weed can cause paranoia and increase the intensity and frequency of thought loops. Furthermore, avoid combining LSD with other drugs as the experience can quickly get out of control. Don't take LSD if you take lithium or antidepressants. Lithium is known to have negative interactions with LSD. Many drugs prescribed as antidepressants have a cancelling effect on LSD, or potential negative effects.[12] [13]

Supplements

  • Cannabidiol: This supplement can greatly help relieve body load discomfort and aid with reducing anxiety. [14]

    • Note the amount of THC your CBD product contains. THC can amplify the trip unpredictably and may cause increased paranoia and thought loops in some people. [15]
  • Passion flower: In extract form, this supplement can greatly help with anxiety. However, it can amplify the trip greatly due to its being a mild MAOI. Use sparingly. Use around 90mg to 100mg in extract form, or 350mg to 500mg of dried passionflower.[16]

  • Magnesium: Like CBD, Magnesium can greatly help with body load discomfort, and can help with anxiety.[17]

  • Arginine and lysine: In combination, these two supplements can work in synergy to help relieve body load caused by vasoconstriction and aid in reducing anxiety before the trip. [18]

  • Ginger: Will help with potential LSD induced nausea. [19]

  • Ibuprofen: Helps with LSD induced vasoconstriction, take a 400mg dose.[20]

Addiction Potential

LSD has no potential for physical addiction, [21] and has low abuse potential. [22]

LSD also develops immediate tolerance after ingestion. It's a good rule of thumb to avoid taking LSD for 1 to 2 weeks until tolerance is reduced back to baseline. Here's a graph which should illustrate this better:

LSD Tolerance Chart

Trip Sitting Advice

If you're trip sitting someone under the influence of LSD and they seem to be having a challenging time, understand that they're heavily intoxicated by the substance. Their perception of reality is skewed, and they might have a hard time recognizing your intentions. If they start saying something that rude or offensive, don't get angry at them or you risk making their state even worse.

Make sure to take a gentle approach to the situation, make sure to comfort them and reassure them that they'll be okay and that they have taken a drug.[23] You may need to remind them multiple times in the case that they forget.

Letting go

If they are experiencing an uncomfortable LSD trip, change the music to something familiar or calm. This would preferably be something without lyrics, as the person tripping may start having delusions of reference [24]. This means that they start believing the lyrics of the song refer to them, increasing paranoia.

Talk with a soft and caring tone. If talking to doesn't offer much help, then just hold the hand of the person having the experience (Warn/ask them first!). This can help calm the person tripping.

Touch

If the person becomes aggressive and becomes physically violent against you, becomes a threat to the public, or starts having a life-threatening condition, you must contact emergency services to help stabilize them. While you may feel the guilt of calling emergency services, the person will eventually understand that it was for their well being.[25]

Effects

During an LSD trip, effects vary from person to person. However, there are some aspects of the experience that are commonly experienced. For this reason, the effects here may not represent every experience.

Entity

Onset (t+ 15 - 30 minutes)

One of the main effects common at this stage is a relaxing yet stimulating body high, like a feeling of built-up energy. Spontaneous giggling may start at this stage. Music euphoria may start to become apparent. Visual distortions may also start to occur. This stage is milder in effects than later parts of the experience.

LSD face

Comeup (t+ 1 - 2.5 hours)

Visuals will start to become more apparent at this stage. Spontaneous giggling and stimulating effects of LSD may get stronger as well. Some visuals at this stage may be the "breathing walls" effect, tracers, color enhancement, warping, or streaks of colors that appear if you stare at a surface for long enough.

Music at this stage can sound more pleasant and immersing. Changes in perception and thought may also become apparent at this point. Some anxiety may surface, it is important to try to remain calm. Thought loops may begin to manifest during this time, and short term memory may become impaired.

LSD art

Vasoconstriction may start to become noticeable, and elevated heartrate may increase at this point.

Peak (t+ 3 - 4 hours)

Visuals are likely to be their strongest in this stage. Spontaneous giggling may become harder to control, if present. The feeling of built-up energy from the onset and come up stage may turn become a slight sedation for some. Time dilation may be apparent, and sometimes overwhelming. Simple tasks may become harder to complete.

LSD Scape

Thought loops are common during this part of the trip. Visuals may consist of complex fractals on surfaces, "flowing" of surfaces (which can be more apparent when looking at wood), heavy breathing effect on vision, extremely vivid colors, and synesthesia (blending of the senses) can occur.

Glyphs, faces, eyes, floral patterns, and "Mayan"-like fractals are reported to be seen for some people.

Mayan Art

It's been reported that the peak may come in waves At points, it may feel as if one is completely sober, before feeling as if the effects have become overwhelmingly strong. This can sometimes happen in cycles.

Vasoconstriction will become stronger during this peak stage.

Food

Heartbeat is typically faster at this point.

Comedown

The comedown can result in a cessation of effects, or lingering effects until the individual goes to sleep. Visuals during the comedown may persist, but the headspace will likely return to a more sober space.

Some people's mood will become worse during the comedown, though others may get an "afterglow" effect

identity

While the trip will be over at this stage, sleeping is typically difficult.

Coping with Bad LSD Experience

WORK IN PROGRESS

Overdose

WORK IN PROGRESS


  1. LSD - HISTORY ↩︎

  2. Neural correlates of the LSD experience revealed by multimodal neuroimaging ↩︎

  3. Is LSD Toxic? ↩︎

  4. Psychedelics and Psychedelic-Assisted Psychotherapy | American Journal of Psychiatry ↩︎

  5. LYSERGIC ACID DIETHYLAMIDE (LSD-25) | American Journal of Psychiatry ↩︎

  6. The Experimental Use of Psychedelic (LSD) Psychotherapy | JAMA | JAMA Network ↩︎

  7. (PDF) Analysis of 25I-NBOMe, 25B-NBOMe, 25C-NBOMe, and other dimethoxyphenyl-N-[(2-methoxyphenyl) methyl]ethanamine derivatives on blotter paper ↩︎

  8. Acute effects of LSD on amygdala activity during processing of fearful stimuli in healthy subjects ↩︎

  9. Benzodiazepine Equivalency Chart: Benzodiazepine Equivalency ↩︎

  10. NIMH » Mental Health Medications ↩︎

  11. Acute induction of anxiety in humans by delta-9-tetrahydrocannabinol related to amygdalar cannabinoid-1 (CB1) receptors | Scientific Reports ↩︎

  12. Alterations in responses to LSD in humans associated with chronic administration of tricyclic antidepressants, monoamine oxidase inhibitors or lithium. ↩︎

  13. LSD and lithium: yet another cautionary tale: LSD ↩︎

  14. Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report ↩︎

  15. Action of cannabidiol on the anxiety and other effects produced by δ 9 -THC in normal subjects | SpringerLink ↩︎

  16. Anxiolytic effects of a passion flower (Passiflora incarnata L.) ...: Ingenta Connect ↩︎

  17. Antidepressant- and anxiolytic-like activity of magnesium in mice - ScienceDirect ↩︎

  18. Subchronic treatment with amino acid mixture of L-lysine and L-arginine modifies neuroendocrine activation during psychosocial stress in subjects with high trait anxiety: Nutritional Neuroscience: Vol 8, No 3 ↩︎

  19. Ginger Supplement — Health Benefits, Dosage, Side Effects | Examine.com ↩︎

  20. Coronary arterial vasodilator effect of ibuprofen. | Journal of Pharmacology and Experimental Therapeutics ↩︎

  21. LSD Addiction | Articles on LSD ↩︎

  22. Hallucinogens - ScienceDirect ↩︎

  23. Human Hallucinogen Research: Guidelines for Safety ↩︎

  24. Delusion of reference - Oxford Reference ↩︎

  25. Therapeutic Touch - Janet Macrae - Google Books ↩︎

Related substances


LSD

10 min read

Lysergic acid diethylamide (Abbreviated as LSD and also called LSD-25, Lucy, L, and Acid) is a psychedelic of the lysergamide family of chemicals. While it was discovered in 1938 by Albert Hofmann, LSD's hallucinogenic properties were not discovered until five years later when Albert Hofmann accidentally ingested the compound ^[[LSD - HISTORY](https://www.history.com/topics/crime/history-of-lsd)]. LSD became an integral symbol of hippie counter-culture later on in the 1960s, as well as becoming a staple of general drug culture. LSD is among the most culturally influential psychedelic drugs in the world. It is believed to change a person's perspective of reality by temporarily inducing a state of interconnection in parts of the brain that don't typically communicate with each other and impacting the effects of multiple neurotransmitters.^[[Neural correlates of the LSD experience revealed by multimodal neuroimaging](https://www.pnas.org/content/early/2016/04/05/1518377113.full?sid=4396f1ed-3885-49bd-bab1-21b161793e12)]

Read